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目的:观察米非司酮治疗绝经过渡期功能失调性子宫出血的临床效果。方法:选择180例确诊为绝期过渡期功能失调性子宫出血患者进行药物治疗,每晚睡前空腹口服米非司酮12.5 mg,每日1次,连服3个月后,每日6.25 mg,再服3个月,共180天为1疗程,治疗前后均检测血常规、尿常规、肝肾功能、卯泡刺激素(FSH)、促黄体生成素(LH)、雌二醇(E2)、血孕酮(P)、泌乳素(PRL)和睾酮(T)。结果:180例中有168例患者服药期间出现暂时性闭经,血红蛋白均有不同程度的提高,停药后月经量恢复正常。治疗后血FSH、LH、E2、P平均水平也较用药前下降,其中E2和P的下降差异具有统计学意义(P<0.05),而PRL、T用药前后变化不明显。结论:米非司酮治疗围绝经期功能失调性子宫出血是一种安全有效的治疗方法,值得临床推广。
Objective: To observe the clinical effect of mifepristone in treating dysfunctional uterine bleeding during menopause. Methods: One hundred and eighty patients with dysfunctional uterine bleeding who were diagnosed as adolescent transitional period were selected for drug treatment. Mifepristone 12.5 mg was given once a day before going to bed at night before bedtime, and once daily for 6 months, , And then for 3 months, a total of 180 days for a course of treatment before and after treatment were detected blood, urine, liver and kidney function, FSH, luteinizing hormone (LH), estradiol (E2) , Blood progesterone (P), prolactin (PRL) and testosterone (T). Results: Among the 180 patients, 168 patients had transient amenorrhea and hemoglobin with varying degrees of improvement. After stopping the medicine, menstruation returned to normal. After treatment, the mean levels of FSH, LH, E2 and P in blood also decreased compared with those before treatment. The difference between E2 and P was statistically significant (P <0.05), but not before and after PRL and T treatment. Conclusion: Mifepristone is a safe and effective treatment for dysfunctional uterine bleeding in perimenopausal period, which is worthy of clinical promotion.