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Dobutamine(多巴酚丁胺)从异丙基肾上腺素合成,对β_1受体有选择性作用,对末稍血管无双相性反应。其血循动力学特征:(1)使心肌收缩力、冠状动脉血流量及心排出量增加;(2)因为窦房结激活或促进传导作用造成心律不明原因的作用较弱;(3)对β_2、α受体作用较弱,有轻度升压作用;(4)促使心脏向肾脏排血量增加,提高肾血流量。是目前较理想的治疗各种不同程度急慢性心功能不全的良药。脑血管虽和其他脏器同样有丰富的植物神经分布,但并不能得到外因性儿茶酚胺的影响,因脑对外周血压的改变有神经、化学、代谢及肌性等极其强烈的自身调节结构的参与,故脑血流量对外周平均动脉压在50～150mmHg时无甚变动。但有脑部血管病、肿瘤或外伤等时,脑循环发生自身调节障碍,
Dobutamine (isobutamine) is synthesized from isoproterenol, has a selective effect on the β 1 receptor, and has no biphasic response to terminal blood vessels. Its hemodynamic characteristics: (1) myocardial contractility, coronary blood flow and cardiac output increased; (2) because of sinus node activation or to promote conduction caused by the role of the cause of unknown heart rhythm weak; (3) β 2, α receptor weak effect, a slight boost; (4) to promote the heart to the kidneys increased blood output, improve renal blood flow. Is the ideal treatment of various degrees of acute and chronic heart failure medicine. Although cerebrovascular has abundant autonomic distribution like other organs, it does not have the effect of extrinsic catecholamines. Due to the changes of cerebral blood pressure, neurons, chemistries, metabolism and muscularity are extremely involved in their own regulatory structures , So the cerebral blood flow on the peripheral mean arterial pressure at 50 ~ 150mmHg little change. However, cerebral vascular disease, cancer or trauma, etc., the cerebral circulation occurs self-regulation disorders,