【摘 要】
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The leading form of dementia worldwide, Alzheimer's disease (AD) is a common neurodegenerative disorder. The underlying causes of AD are not well understood, an
【机 构】
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Centre for Brain Research,Department of Anatomy and Medical Imaging,Faculty of Medical and Health Sc
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The leading form of dementia worldwide, Alzheimer's disease (AD) is a common neurodegenerative disorder. The underlying causes of AD are not well understood, and no current treatments are preventing the onset or delay progression of the disease. Currently, most investigation is directed towards the amyloid-beta (Aβ) and tau pathologies, yet there are many other underlying processes that have been implicated to contribute directly to AD progression. One such phenomenon is glutamatergic excitotoxicity, a loss of neuromodulatory balance inducing a hyper-excitable neuronal state, leading to cell death across several brain regions (Zhang et al., 2016; Bukke et al., 2020).
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