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目的:观察中医药在防治母儿ABO血型不合方面的疗效以及产前用药对新生儿黄疸的影响。方法:对335例母儿血型不合病例进行回顾性分析,其中产前采用中药防治母儿血型不合的221例为治疗组,余为对照组,观察孕妇ABO抗体效价的变化、新生儿病理性黄疸的发生情况及黄疸程度。结果:本院中药降低血清抗体效价有效率为97.7%;治疗组较对照组新生儿病理性黄疸的发生率明显降低(P﹤0.05);两组发生病理性黄疸的病例,其黄疸程度无明显差异(P﹥0.05);分娩前最后一次血清抗体效价与新生儿血清总胆红素线性相关分析,两者不存在线性回归关系(P﹥0.05)。结论:产前中药防治母儿ABO血型不合能有效的降低血清抗体效价,减少新生儿病理性黄疸的发生;产前用药不能减轻新生儿病理性黄疸的程度,需要对新生儿进行干预,阻断新生儿黄疸的进程。
Objective: To observe the curative effect of traditional Chinese medicine (TCM) on prevention and treatment of maternal-ABO blood group incompatibility and the effect of prenatal medication on neonatal jaundice. Methods: A retrospective analysis was performed on 335 cases of maternal and child blood group incompatibility. Among them, 221 cases were treated with traditional Chinese medicine to prevent and control maternal-blood incompatibility in the prenatal period, and the rest were control group. The changes of ABO antibody titers in pregnant women, The incidence of jaundice and jaundice. Results: The effective rate of Chinese medicine for reducing serum antibody titer was 97.7%. The incidence of neonatal pathological jaundice in the treatment group was significantly lower than that in the control group (P <0.05). There was no significant difference in the incidence of pathological jaundice (P> 0.05). There was no linear regression between the serum antibody titers before delivery and neonatal total serum bilirubin (P> 0.05). Conclusion: Prenatal Chinese medicine prevent ABO blood group incompatibility can effectively reduce serum antibody titer and reduce the incidence of neonatal pathological jaundice; prenatal medication can not reduce the degree of neonatal pathological jaundice, the need for neonatal intervention, resistance Newborn jaundice process.