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目的:观察腺苷蛋氨酸治疗婴儿巨细胞病毒性肝炎的临床疗效。方法:将82例婴儿巨细胞病毒性肝炎患儿采取随机双盲法分为治疗组46例和对照组36例,两组均给予更昔洛韦抗感染,茵栀黄退黄,对照组给予门冬氨酸钾镁保肝治疗,治疗组给予腺苷蛋氨酸保肝治疗,每组治疗10 d,每天一次。比较治疗前后两组肝功能各项指标的变化。结果:治疗前两组肝功能指标比较均无统计学差异(P>0.05);治疗后治疗组肝功能指标明显下降,较对照组有显著统计学差异(P<0.05)。结论:腺苷蛋氨酸治疗婴儿巨细胞病毒性肝炎安全有效,且不良反应少。
Objective: To observe the clinical efficacy of adenosine methionine in the treatment of infantile cytomegalovirus hepatitis. Methods: Eighty-two infants with cytomegalovirus hepatitis were divided into treatment group (46 cases) and control group (36 cases) by randomized double-blind method. Both groups were given ganciclovir anti-infection, Aspartate potassium magnesium liver treatment, the treatment group given adenosine methionine liver protection, each treatment for 10 d, once daily. Before and after treatment, the changes of liver function indexes in both groups were compared. Results: There was no significant difference in liver function index between the two groups before treatment (P> 0.05). The liver function index of the treatment group decreased significantly after treatment, which was significantly different from the control group (P <0.05). CONCLUSION: Adenosine methionine is safe and effective in the treatment of infantile cytomegalovirus hepatitis with few adverse reactions.