收集４０例内镜确诊为胃十二指肠溃疡病人，随机分成两组，分别予泰胃美、奥美拉唑口服；干服药前后分别行胃镜检查，并抽吸胃液行需氧菌、厌氧菌及真菌培养。结果示：胃液细菌量及硝酸盐还原菌量与胃液ｐＨ值呈正相关（ｒ＝０．８０２和０．７，ｐ＜０．０１），抗胃酸分泌药物尤以奥美拉唑引起胃内菌量增加明显。临床治疗消化性溃疡时，应注意胃内微生态防治。 40 cases of endoscopic diagnosis of gastroduodenal ulcer patients were collected, were randomly divided into two groups were given to Wei Mei, omeprazole oral; dry medication before and after gastroscopy, respectively, and gastric juice aerobic aerobics, tired Oxygen bacteria and fungi culture. The results showed that there was a positive correlation between the amount of bacteria in the gastric juice and the amount of nitrate-reducing bacteria and the pH value of gastric juice (r = 0.802 and 0.7, p <0.01). The gastric acid-secreting drugs, especially omeprazole, The amount increased significantly. Clinical treatment of peptic ulcer should pay attention to the stomach micro-ecological control.