论文部分内容阅读
目的探讨直肠炎性肌纤维母细胞性肿瘤(IMT)的临床病理特征。方法对1例IMT进行临床、组织学和免疫组化观察,并复习相关文献。结果患者女性,36岁。临床表现为腹痛伴黏液血便半个月。肠镜检查示距肛门15 cm处可见5 cm×4 cm大小的息肉样肿块,表面高低不平。镜检:肿瘤组织主要由束状交错排列的梭形细胞组成,背景为黏液样基质及大量淋巴细胞、浆细胞浸润。免疫组化:梭形细胞vimentin、SMA和desmin(+),Ki-67阳性指数为20%,而ALK1、CD117、KP1、CD30、CD34、AE1/AE3、myogenin、H-caldesmon和HMB45均为(-)。术后随访18个月未复发。结论炎性肌纤维母细胞性肿瘤罕见于直肠,易被临床医师误诊为恶性肿瘤。免疫组化结果是该肿瘤与其他软组织肿瘤鉴别的重要依据。
Objective To investigate the clinicopathological features of rectal inflammatory myofibroblastic tumor (IMT). Methods One case of IMT was observed clinically, histologically and immunohistochemically and related literature was reviewed. Results Patients Female, 36 years old. Clinical manifestations of abdominal pain with mucus bloody half a month. Colonoscopy revealed an obstruction of 5 cm × 4 cm in size from the anus at 15 cm. The surface was rugged. Microscopic examination: Tumor tissue mainly composed of bundles of spindle-shaped staggered cells, the background for the mucus-like matrix and a large number of lymphocytes, plasma cells infiltration. Immunohistochemistry showed that vimentin, SMA, desmin (+) and Ki-67 positive index of spindle cells were 20%, while ALK1, CD117, KP1, CD30, CD34, AE1 / AE3, myogenin, H-caldesmon and HMB45 were all ( -). No follow-up 18 months follow-up. Conclusion Inflammatory myofibroblastic tumors rarely occur in the rectum and are easily misdiagnosed as malignant tumors by clinicians. Immunohistochemical results of the tumor and other soft tissue tumors important basis for the identification.