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脂布福吉宁是从传统中药蟾酥中分离的单一化合物。长期以来,蟾酥制品广泛应用于中国、日本及亚洲其他国家。但是,近来在美国出现一些有关蟾酥及其药物制剂引起中毒的报告。如洋地黄一样,脂布福吉宁也具有药理和毒理作用。根据我们的实验结果,高浓度脂布福吉宁,蟾酥的主要成分之一,可以引起离体心肌细胞和在体心脏的延时性后去极化及触发性心律失常。本文对引起毒性的可能机制及治疗心律失常的可能性也进行了讨论。
Lipbufuginin is a single compound isolated from the traditional Chinese herbal wolfberry. For a long time, the crisp products have been widely used in China, Japan and other Asian countries. However, recently there have been reports of poisoning caused by eucalyptus and its pharmaceutical preparations in the United States. Like digitalis, fatbukinin also has pharmacological and toxicological effects. According to our experimental results, one of the main components of high-strength fat bupivacin and konjac may cause delayed post-depolarization and triggered arrhythmia in isolated cardiac myocytes and in vivo hearts. This article also discusses the possible mechanisms that cause toxicity and the possibility of treating arrhythmias.