着色性干皮病(Xeroderma pigmentosum)是一种罕见的遗传性疾病,常在一个家族中多人发病,临床特点为儿童时期开始发生雀斑状皮疹,毛细血管扩张,皮肤干燥萎缩及疣状赘生。重症患者到后期在面部可以发生癌变或由色素斑转化为黑色素瘤。我院曾见亲兄弟二人同患本病(皮肤科会诊确诊),其弟眼部并发恶性黑色素 Xeroderma pigmentosum is a rare hereditary disease, which often occurs in more than one family. The clinical features of the disease are childhood: freckles rash, telangiectasia, dry skin shrinkage, and verrucous growth. . Severe patients may develop cancer on the face or metastasis from melasma to melanoma. Our hospital had seen two brothers with the same disease (definition diagnosed by the Department of Dermatology), and his brother’s eye developed malignant melanin.