本文对工业性致癌物质进行了历史性回顾。1775年 Pott 首次提出烟灰可使扫烟囱者发生阴囊癌,1795年又有焦油可致唇癌,砷剂可引起其他类型癌瘤的报告。1902年电离辐射也被列为致癌因子。除电离辐射外,这些物质的大多数现在都不认为是真正的致癌物质。这些都需要辅助致癌因子(co-carcinogen),如外伤对扫烟囱患者,紫外线对焦油和砷剂的作用。碳氢化物如煤、焦油、石蜡油、滑润油、沥青及杂酚油已被证明为工业中的致 This article has a historical review of industrial carcinogens. In 1775, Pott first proposed that soot could cause scrotal cancer in chimney sweepers. In 1795, tar could cause lip cancer. Arsenic can cause reports of other types of cancers. Ionizing radiation was also listed as a carcinogenic factor in 1902. With the exception of ionizing radiation, most of these substances are now not considered to be genuine carcinogens. These all require the help of co-carcinogens, such as the effect of trauma on chimney smokers, UV tar and arsenic. Hydrocarbons such as coal, tar, paraffin oil, lubricating oil, bitumen and creosote have been proven to be industrially