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目的探讨非甾体类消炎药(NSAIDs)相关性下消化道损伤的情况。方法选取46例我院行胶囊内镜检查的患者,其中,28例因高血压及冠心病服用阿司匹林100 mg,每日1次,其中服药持续时间小于6月15例,大于6月13例,另18例患者未服用阿司匹林等非甾体类消炎药,分析下消化道出血及糜烂、溃疡等病变情况。结果服药持续时间小于6月15例患者,下消化道出血及糜烂、溃疡有5例,发生率33.3%;服药时间大于6月13例患者,下消化道出血及糜烂、溃疡有8例,发生率61.5%,两组间有显著性差异(P<0.01),另18例患者未服用阿司匹林等非甾体类消炎药者下消化道出血及糜烂、溃疡2例,发生率11.1%,与服药组比较亦有显著性差异(P<0.01)。结论 NSAIDs所致下消化道损伤明显高于未服用该类药物者,且服药时间越长,其发生率越高。
Objective To investigate the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on gastrointestinal injury. Methods 46 cases of our hospital capsule endoscopy in patients, of which 28 cases of hypertension and coronary heart disease taking aspirin 100 mg once daily, of which the duration of medication was less than in June 15 cases, more than in June 13 cases, The other 18 patients did not take aspirin and other non-steroidal anti-inflammatory drugs, analysis of lower gastrointestinal bleeding and erosion, ulcers and other lesions. Results The duration of medication was less than 15 cases in June. The lower gastrointestinal bleeding and erosion, ulcer in 5 cases, the incidence rate of 33.3%; taking more than 6 months in 13 patients, lower gastrointestinal bleeding and erosion, ulcers in 8 cases occurred Rate of 61.5%, there was a significant difference between the two groups (P <0.01), and the other 18 patients did not take aspirin and other non-steroidal anti-inflammatory drugs, lower gastrointestinal bleeding and erosion, ulcer in 2 cases, the incidence rate of 11.1% There were also significant differences between groups (P <0.01). Conclusions NSAIDs induced lower GI lesions were significantly higher than those who did not take these drugs, and the longer the medication, the higher the incidence.