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本文对腹腔注射氯化钴(每日5mg/kg)大鼠心肌病和过氧化反应的关系进行了研究。在注射钴次3和5次后血浆磷酸肌酸激酶和谷草转氨酶活性增高。注射钴7次后,心肌脂质染色增强,部分动物心脏显示形态学异常和琥珀酸脱氢酶反应减弱;心肌游离脂肪酸和血清维生素 E 含量增加.心肌硒含量和超氧物歧化酶活性均无改变。心肌谷胱甘肽过氧化物酶活性在注射钴3次和5次后也无变化;尽管在注射钴7次后其活性下降,但心肌脂质过氧化物水平并不升高。结果表明钴对心肌的损害作用与脂质过氧化物的形成无明显关系.
In this paper, the relationship between cardiomyopathy and peroxidation in rats injected intraperitoneally with cobalt chloride (5 mg/kg daily) was studied. Plasma creatine kinase and aspartate aminotransferase activity increased after 3 and 5 injections of cobalt. After 7 injections of cobalt, myocardial lipid staining was enhanced, some animal hearts showed morphological abnormalities and succinate dehydrogenase reaction was weakened; myocardial free fatty acids and serum vitamin E content were increased. Myocardium selenium content and superoxide dismutase activity were not change. Myocardial glutathione peroxidase activity did not change after 3 and 5 injections of cobalt; although the activity decreased after 7 injections of cobalt, myocardial lipid peroxide levels did not increase. The results showed that the effect of cobalt on myocardium was not related to the formation of lipid peroxides.