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将健康家猫28只共56眼随机分成7组,除正常对照组外,其余6组48眼制成高眼压模型。用荧光眼底血管造影观察正常眼压及高眼压持续24h及48h的眼底血管荧光图像,用微机图像分析系统定量测定视神经轴突直径、总数及占视神经面积百分率;透射电镜观察视神经轴突超微结构。结果显示高眼压持续24h及48h的猫眼底荧光血管造影与正常眼压时无明显差异,而高眼压持续24h后,视神经轴突即可出现明显改变,其直径增大、数量减少、占视神经面积的百分率降低(P<0.05);高眼压持续时间越长轴突损害越严重(P<0.001),两者呈显著相关。透射电镜检查发现高眼压持续24h后,视神经轴突的超微结构较正常有明显改变。高眼压持续时间延长,改变越明显。提示高眼压是造成视神经轴突损害的重要原因,因此对青光眼的治疗应尽早采取积极地降低眼压措施。
A total of 56 healthy domestic cats, a total of 56 were randomly divided into 7 groups, in addition to the normal control group, the remaining 6 groups of 48 eyes made high intraocular pressure model. Fluorescent fundus angiography was used to observe the ocular fundus fluorescein images with normal intraocular pressure and high intraocular pressure for 24h and 48h. The diameter, total number and area percentage of optic nerve axon were quantitatively determined by computerized image analysis system. The ultrastructure of optic nerve axon structure. The results showed that there was no significant difference between ocular fundus fluorescein angiography and normal intraocular pressure when the intraocular pressure was maintained at 24h and 48h, while the intraocular pressure was significantly changed after the intraocular pressure was maintained for 24h, the diameter increased and the number decreased The percentage of optic nerve area decreased (P <0.05). The longer the duration of ocular hypertension was, the more severe the axonal damage was (P <0.001). Transmission electron microscopy showed that elevated intraocular pressure for 24h, the optic nerve axon ultrastructure was significantly changed than normal. High intraocular pressure to extend the duration, the more obvious changes. Tip high intraocular pressure is an important cause of optic nerve damage, so the treatment of glaucoma should take positive measures to reduce intraocular pressure as soon as possible.