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目的观察代偿期肝炎肝硬化患者应用盐酸普萘洛尔、安体舒通联合安络化纤丸治疗后临床症状、体征、肝功能、血清肝纤维化指标的恢复情况和肝脏、脾脏影象学改变。方法将120名代偿期肝硬化患者分为两组,治疗组60例患者口服盐酸普萘洛尔(10mg/次,3次/d)、安体舒通(20mg/次,3次/d)、安络化纤丸(6g/次,2次/d);对照组60例接受丹参片治疗(3片/次,3次/d)。两组疗程均为6个月。结果盐酸普萘洛尔、安体舒通联合安络化纤丸治疗后血清透明质酸酶(HA)、层黏蛋白(LN)和Ⅲ型前胶原(PC-Ⅲ)平均水平下降十分显著,HA尤为突出,与对照组比较P<0.05;肝脏、脾脏影象学检查有显著改善,与对照组比,P<0.01。结论盐酸普萘洛尔、安体舒通联合安络化纤丸有较好的抗肝硬化效果。
Objective To observe the recovery of clinical symptoms, signs, liver function, serum liver fibrosis indexes and the imaging of liver and spleen after treatment with propranolol hydrochloride and spironolactone in combination with Anluo Huaxian Pills in patients with decompensated hepatitis and liver cirrhosis change. Methods 120 patients with decompensated cirrhosis were divided into two groups. 60 patients in the treatment group were treated with propranolol hydrochloride (10 mg / time, 3 times / d), spironolactone (20 mg / time, 3 times / d ), Anluo Chemical Fiber Pills (6g / time, twice / d); control group of 60 patients received Danshen tablets treatment (3 tablets / time, 3 times / d). Two courses of treatment are 6 months. Results The average level of serum hyaluronidase (HA), laminin (LN) and type Ⅲ procollagen (PC-Ⅲ) decreased significantly after treatment with propranolol hydrochloride and spironolactone combined with Anluo Huaxian Pill. HA Especially in the control group (P <0.05). The imaging examination of the liver and spleen showed a significant improvement compared with the control group (P <0.01). Conclusions Propranolol hydrochloride and spironolactone combined with Anluo Huaxian Pills have better anti-liver cirrhosis effect.