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回顾性研究了４９例原诊断为神经母细胞瘤（ＮＢ），神经节神经母细胞瘤（ＧＮＢ）和神经节细胞瘤（ＧＮ）的病理资料。结果表明，这３种肿瘤为分化程度不同的同源性肿瘤，统称为神经母细胞瘤。应用免疫组化方法检测ＮＳＥ、Ｓ－１００、ＣＧＡ和ｐ５３、Ｃ－ｅｒｂ－Ｂ２、ｐ２１在该肿瘤中的表达和分布，发现ＮＳＥ、Ｓ－１００和ＣＧＡ阳性率分别为８５％、７３％和５０％，在肿瘤的Ⅰ～Ⅳ级之间，分化越好者阳性率越高（Ｐ＜０．０５），可做为临床鉴别诊断的估计预后的指标；ｐ５３、Ｃ－ｅｒｂ－Ｂ２和ｐ２１在肿瘤各级中均有表达，提示在该肿瘤发生中抑癌基因突变和原癌基因激活起一定的作用，其中低分化组ｐ５３蛋白的表达明显强于高分化组（Ｐ＜０．０５），亦可做为估计肿瘤预后的指标
The pathological data of 49 patients with neuroblastoma (NB), ganglioneuroblastoma (GNB) and ganglioneuroblastoma (GN) were retrospectively studied. The results showed that these three kinds of tumors with different degrees of differentiation of homologous tumors, collectively referred to as neuroblastoma. The expression and distribution of NSE, S-100, CGA and p53, C-erb-B2 and p21 in this tumor were detected by immunohistochemistry. The positive rates of NSE, S-100 and CGA were 85%, 73% (P <0.05). The positive rates of p53, C-erb-B2 and p21 (P <0.05) can be used as the prognostic indicators in clinical differential diagnosis. The expression of p53 protein in the poorly differentiated group was significantly higher than that in the well-differentiated group (P <0.05) , Can also be used as an indicator of tumor prognosis