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以１０ｇ／Ｌ高纯度氧化铍粉尘生理盐水混悬液经气管注入制成的豚鼠实验性铍肺模型，在病理上早期主要是支气管、肺的炎性改变，４及６周时肺内肉芽肿结节形成，１０周时电镜下见肺间质有少量胶原增生。染毒后１、１０周时ＢＡＬＦ中ＨＡ、ＦＮ及ＬＭ水平测定结果见ＨＡ在１周炎症水肿期及１０周肺间质纤维化早期均显著增高，与对照组相比差异十分显著（Ｐ＜０．０１）。ＦＮ水平仅于炎症水肿期明显增高，与对照组相比，差异有显著性（Ｐ＜０．０５），而ＬＭ水平在染毒组与对照组间差异无显著性（Ｐ＞０．０５）。ＨＡ在反映肺间质疾病活动和进展上可能是较ＦＮ、ＬＭ更敏感的指标。
The experimental beryllium lung model of guinea pig with 10g / L high purity beryllium oxide dust physiological saline suspension injected through the trachea was predominantly bronchial and pulmonary inflammatory changes at the early stage of the pathology. Pulmonary granuloma at 4 and 6 weeks Nodules formed, 10 weeks, under electron microscopy showed a small amount of interstitial collagen hyperplasia. The levels of HA, FN and LM in BALF at 1 week and 10 weeks after exposure were all significantly higher in HA edema at 1 week and at the early 10 weeks than those in control group (P < 0.01). The level of FN was only increased in the period of inflammatory edema, which was significantly different from that in the control group (P <0.05), while there was no significant difference in the level of LM between the treated group and the control group (P> 0.05) . HA reflects the activity and progress of interstitial lung disease may be more sensitive than FN, LM indicators.