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作者用“Guanethidine”(Ismelin)(胍乙啶)治疗62例高血压患者,其中43例为原发性高血压,19例为肾性高血压。该药的使用剂量为每天10～25毫克,个别患者每天用到200毫克,常用量为每天50～70毫克。用药期限一般为4～6周。其中有59例有明显的降压效果,38例血压降到正常,恶性高血压、肾孟肾炎和广泛性肾小球肾炎各一例皆无效。罕见而严重的併发症是直立性虚脫。此药有蓄积作用,可抑制交感神经的活动。最后作者建议为了避免直立性虛脱,在患者下肢应用强力绷带,并教导病人避免突然采取直立姿式,并减少该药的应用剂量。
The authors treated 62 patients with hypertension with “Guanethidine” (Isetlin), of which 43 were essential hypertension and 19 were renal hypertension. The drug dose of 10 to 25 mg daily, individual patients use 200 mg daily, the usual daily dose of 50 to 70 mg. Medication period is generally 4 to 6 weeks. Among them, 59 cases had obvious antihypertensive effects, 38 cases of blood pressure dropped to normal, malignant hypertension, renal mesangial nephritis and extensive glomerulonephritis in each case were invalid. Rare and serious complication is erection collapse. The drug has a cumulative effect, can inhibit the activity of sympathetic. Finally, the authors suggest that in order to avoid orthostatic collapse, strong bandages are applied to the lower extremities of the patient and the patient is taught not to take a sudden upright posture and to reduce the dose of the drug.