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作者选择健康成年献血员113名;慢性活动性肝炎30例,其中HB_sAg阳性20例,阴性10例。观察了纯化的人血清α_2-巨球蛋白(α_2M)对不同丝裂原刺激的淋巴细胞转化反应的影响,证实α_M具有剂量相关性抑制细胞免疫的功能。经免疫荧光技术证实了T细胞表面结合有α_2M。免疫化学法检查30例慢性活动性肝炎患者血清α_2M,其中8例(7例HB_sAg阳性)较正常对照高。自身对照研究表明,应用特异性抗体结合α_2M后,慢
The authors selected 113 healthy adult blood donors; chronic active hepatitis in 30 cases, of which 20 cases of positive HB_sAg, negative in 10 cases. The effect of purified human α_2-macroglobulin (α_2M) on lymphocyte stimulated by different mitogen stimuli was observed, indicating that α_M has the function of dose-dependent inhibition of cellular immunity. Confirmed by immunofluorescence T cell surface binding α 2 M. Immunohistochemistry was used to examine the serum levels of α_2M in 30 patients with chronic active hepatitis, of which 8 (7 HBsAg positive) were higher than the normal controls. Self-control studies have shown that the use of specific antibodies after binding α_2M, slow