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目的:观察银杏叶制剂对肿瘤化疗患者血浆TGF-β1、肺功能和肺部影像学的影响。方法:77例患者平行对照分为两组,化疗对照组41例,化疗联合银杏叶制剂实验组36例。每个病例均接受本研究需要观察的化疗药物,治疗至少2个以上周期。观察两组患者化疗前后血浆TGF-β1水平的变化、肺功能和肺部影像学改变的发生情况。结果:未应用银杏叶制剂的化疗患者化疗后TGF-β1水平较化疗前明显升高(P<0.05);而应用银杏叶制剂联合化疗的实验组患者化疗前后TGF-β1水平无明显变化(P>0.05),两组中未发生影像学肺间质病变病例的TGF-β1比较差异有统计学意义(P<0.05);化疗组对照组发生影像学肺间质病变病例的TGF-β1比未发生影像学肺间质病变的病例升高明显(P<0.05);两组中发生影像学肺间质病变病例的TGF-β1比较差异无统计学意义(P>0.05);银杏叶制剂组发生影像学肺间质病变病例的TGF-β1比未发生影像学肺间质病变的病例升高明显(P<0.05);而两组的肺功能改变、呼吸困难及影像学改变之间的差异无统计意义(P>0.05)。结论:化疗同时应用银杏叶制剂能有效抑制血浆TGF-β1升高,减少肺间质病变的发生率,减轻化疗的毒副作用。
Objective: To observe the effect of Ginkgo biloba extract on plasma TGF-β1, pulmonary function and pulmonary imaging in patients with tumor chemotherapy. Methods: 77 patients were divided into two groups according to the parallel control. The control group was 41 and the chemotherapy combined with ginkgo leaf preparation group was 36. Each case received chemotherapy drugs to be observed in this study for at least 2 cycles. The change of plasma TGF-β1 level before and after chemotherapy was observed in both groups, and the pulmonary function and pulmonary imaging changes were observed. Results: The levels of TGF-β1 in patients with chemotherapy without Ginkgo biloba were significantly higher than those before chemotherapy (P <0.05), while the levels of TGF-β1 in patients with Ginkgo biloba combined with chemotherapy did not change significantly > 0.05). There were significant differences in TGF-β1 between the two groups (P <0.05). There was no significant difference between the two groups in the incidence of pulmonary interstitial disease There was a significant increase in the number of pulmonary interstitial lesions (P <0.05). There was no significant difference in TGF-β1 between the two groups (P> 0.05); in the group of Ginkgo biloba Imaging TGF-β1 in patients with interstitial lung disease was significantly higher than that in patients without pulmonary disease (P <0.05). There was no significant difference in pulmonary function, dyspnea and imaging between the two groups Statistical significance (P> 0.05). Conclusion: Chemotherapy combined with Ginkgo biloba preparation can effectively inhibit the increase of plasma TGF-β1, reduce the incidence of interstitial lung disease and reduce the side effects of chemotherapy.