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早在1929年,Boreri就提出染色体的变化在肿瘤形成时起重要作用的假说。然而,若在人体确切地证实这一理论,还有待于细胞遗传学,特别是肿瘤细胞遗传学的发展。1952年Makino根据可移植的动物肿瘤细胞染色体广泛的研究,发现每一肿瘤都是以特异的染色体结构为特征的。Nowell和Hungford发现在慢性粒细胞白血病(CML)与某一特异标志(费城染色体,Ph′)有稳定联系时指出:在特异的肿瘤发生中,从病因学方面,涉及到染色体的改变。70年代,通过人类中期染色体显带方法(250～
As early as 1929, Boreri proposed the hypothesis that chromosomal changes play an important role in tumorigenesis. However, if this theory is confirmed in the human body, the development of cytogenetics, especially tumor cytogenetics, remains to be done. In 1952 Makino based on a wide range of portable animal tumor cell chromosomes found that each tumor is characterized by a specific chromosomal structure. Nowell and Hungford found that chronic myeloid leukemia (CML) has a stable association with a specific marker (Philadelphia chromosome, Ph ’): In a specific tumorigenesis, the etiology is related to chromosomal changes. 70’s, through the human metaphase chromosome banding method (250 ~