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调查１５７名在燃煤型地氟病区出生和长大的１２～１３岁儿童，并作动物高氟摄入实验。结果发现：从童年早期开始的长期高氟摄入会引起儿童脑力工作能力降低；长期摄入高氟的儿童发锌含量下降。多元相关分析表明，儿童脑力工作能力与发锌呈正相关。同时，长期高氟摄入的动物脑中５—羟吲哚乙酸降低和去甲肾上腺素增高，这可能是使儿童脑力工作能力降低的作用机理，需进一步实验证实。
A total of 157 children aged 12 to 13 who were born and raised in land-based fluoridation ward were surveyed and animals were experimented with high fluoride intake. The results showed that long-term high fluoride intake from the early childhood led to a decrease in children’s mental ability to work, and children with long-term high fluoride intake had a decreased zinc content. Multivariate correlation analysis showed that children’s mental ability to work was positively correlated with zinc production. At the same time, the decrease of 5-hydroxyindole-acetic acid and the increase of norepinephrine in the brain of animals exposed to long-term high fluoride may be the mechanism of reducing the mental working ability of children, which needs further experiments to confirm.