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目的对菝葜不同工艺提取物治疗妇科盆腔炎的药理作用进行对比研究,为确定菝葜的最佳提取工艺提供参考。方法采用不同工艺制备菝葜提取物,观察其对常见妇科感染菌的体外抑菌作用;子宫注射混合菌液法制备大鼠盆腔炎模型,观察菝葜不同工艺提取物对子宫炎症、组织病理学及血液流变学各指标的影响。结果不同工艺菝葜提取物对多种妇科感染菌均有一定的抑菌作用;对子宫内膜炎症均有较好抑制作用,能减轻子宫肿胀及组织的病变程度,并能降低模型大鼠全血黏度和全血还原黏度。结论不同工艺制备的菝葜提取物均对妇科盆腔炎症有一定的治疗作用,以水提醇沉工艺制备的提取物作用最为明显。
OBJECTIVE To compare the pharmacological effects of different extracts from Gynostemma on the treatment of gynecological pelvic inflammatory disease, and to provide a reference for the determination of the optimal extraction process of Gynura sylvatica. Methods The extract of Dioscorea nipponica was prepared by different techniques, and its antibacterial activity against common gynecological infections was observed in vitro. The model of pelvic inflammatory disease was prepared by uterine injection of mixed bacterium solution. The effects of different extracts from Dioscorea zingiberensis on uterine inflammation, histopathology And the impact of various indicators of hemorheology. Results The extracts from different technologies had some antibacterial effects on many kinds of gynecological infections, inhibited the inflammation of the endometrium, reduced the swelling of the uterus and the degree of tissue lesions, Blood viscosity and whole blood reduction viscosity. Conclusion All the extracts of Dioscorea nipponica prepared by different techniques have a certain therapeutic effect on gynecologic pelvic inflammatory disease. The extract prepared by water-alcohol precipitation process is the most obvious.