雌激素对骨代谢作用的明确机理尚不明瞭。近年对成骨细胞样细胞中雌激素受体的研究表明,雌激素通过其在骨细胞中的受体而有直接对骨代谢起作用的潜力。人们已了解雌激素对骨质疏松骨具有保护作用,但对其在骨折愈合过程中的存在及作用机理还需研究。本文作者采用改良的反转录和多聚酶链反应放大技术,检测20例雄性L-E大鼠骨折后骨痂内雌激素受体mRNA含量。用限制消化技术准确放 The exact mechanism by which estrogen exerts its effect on bone metabolism is unclear. Recent studies of estrogen receptors in osteoblast-like cells show that estrogen has a potential to directly affect bone metabolism through its receptor in bone cells. It is understood that estrogen has a protective effect on osteoporosis bone, but its existence and mechanism in the process of fracture healing need to be studied. The authors used modified reverse transcription and polymerase chain reaction amplification techniques to detect estrogen receptor mRNA content in callus of 20 male L-E rats after fracture. Use restriction digestion technology to accurately put