论文部分内容阅读
目的利用文本挖掘方法,对干细胞的研究热点及研究趋势做出分析判断。方法以Pubmed数据库为数据来源,检索2003年1月1日-2012年7月13日的干细胞研究文献,提取相关题录信息,判定高频主题词,生成共现矩阵、共词聚类,并进行共词聚类分析。结果数据分析显示,干细胞治疗、细胞移植、干细胞神经系统一直是高频主题词。2008年之后,细胞变异和免疫系统两个类团不再出现,新增了细胞分化、造血干细胞、骨髓干细胞、干细胞调控因子4个类团。结论干细胞治疗、细胞移植、干细胞神经系统是干细胞领域的研究热点;干细胞研究正由简单的基础研究、应用研究转向更复杂的细胞分化、细胞调控、细胞移植等方向的研究。
Objective To analyze and judge the research hot spots and research trends of stem cells by using text mining method. Methods Pubmed database was used as a data source to retrieve the literature of stem cell research from January 1, 2003 to July 13, 2012, to extract relevant bibliographic information, to identify high frequency keywords, to generate co-occurrence matrix and co-word clustering, and to Co-word cluster analysis. Results Data analysis showed that stem cell therapy, cell transplantation, stem cell nervous system has been a high frequency topic. After 2008, the two groups of cell mutation and immune system no longer appear. Four groups of cell differentiation, hematopoietic stem cells, bone marrow stem cells and stem cell regulators were added. Conclusion Stem cell therapy, cell transplantation and stem cell nervous system are hot topics in the field of stem cells. Stem cell research is shifting from simple basic research and applied research to more complex cell differentiation, cell regulation and cell transplantation.