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目的 :探讨健胃愈疡颗粒 (JYG)抗消化性溃疡 (PU)复发的机制。方法 :以白细胞介素 lβ(IL 1β)所致胃溃疡复发大鼠为模型 ,以JYG、胃苏颗粒治疗干预 ,取胃组织检测胃溃疡指数 (GUI)、bcl 2、bax的表达。临床观察随机分为JYG组和洛赛克组 ,服药 4周 ,取胃粘膜组织检测fas/fasL、雌激素结合蛋白 (hTFF1)、表皮生长因子受体 (EGFR)的表达。结果 :JYG可使胃GUI、溃疡复发率明显降低 ,临床疗效和溃疡愈合率与西药组相当 ,但一年随访复发率明显低于对照组。JYG增加胃粘膜凋亡相关蛋白bcl 2、hTFF1、EGFR蛋白表达 ,提高bcl 2 /bax比值 ,使胃粘膜上皮细胞凋亡减少 ;改善溃疡愈合后再生粘膜组织成熟度。与对照组比较差异有统计学意义。能显著降低肝郁脾虚或肝胃不和的幽门螺杆菌 (Hp)阳性PU患者胃粘膜组织fas/fasL蛋白的表达。 结论 :JYG可通过调节凋亡相关蛋白表达 ,改善溃疡愈合质量 ,从多种途径抗溃疡及溃疡复发
Objective: To investigate the mechanism of JYG anti-peptic ulcer (PU) recurrence. Methods :The model of gastric ulcer recurrence rats induced by interleukin 1β(IL 1β) was treated with JYG and Weisu granules. Gastric tissue was used to detect gastric ulcer index (GUI), bcl 2 and bax expression. Clinical observations were randomly divided into JYG group and Losec group. After taking the drugs for 4 weeks, gastric mucosal tissues were used to detect the expression of fas/fasL, estrogen binding protein (hTFF1) and epidermal growth factor receptor (EGFR). Results: JYG could significantly reduce the recurrence rate of GUI and ulcers in the stomach, and the clinical efficacy and ulcer healing rate were similar to those of western medicine group. However, the recurrence rate of one year follow-up was significantly lower than that of the control group. JYG increased expression of apoptosis-related proteins bcl 2, hTFF1, and EGFR of gastric mucosa, increased bcl 2 /bax ratio, decreased apoptosis of gastric epithelial cells, and improved mucosal tissue maturation after ulcer healing. Compared with the control group, the difference was statistically significant. It can significantly reduce the expression of fas/fasL protein in gastric mucosa of patients with Helicobacter pylori (Hp) positive PU with hepatic stagnation and spleen deficiency or hepatogastric disharmony. Conclusion : JYG can improve the quality of ulcer healing by regulating the expression of apoptosis-related proteins, anti-ulcer and ulcer recurrence from multiple pathways