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目的探讨经直肠高强度聚焦超声联合内分泌疗法与单纯内分泌疗法治疗前列腺癌的疗效。方法将40例前列腺癌患者分为A、B两组,其中A组采用HIFU联合内分泌治疗,B组采用单纯内分泌治疗。HIFU治疗采用Sonablate 500型经直肠HIFU治疗系统,内分泌治疗采用去势加用抗雄激素药物治疗。随访时间8～24个月,平均16个月。结果A、B两组患者在治疗后,均出现了前列腺体积缩小,血清PSA均有不同程度下降,IPSS评分降低,Qmax明显提高,治疗前后差异有统计学意义(P<0.05)。其中A组较B组改变更为明显,两者之间差异有统计学意义(P<0.05)。结论高强度聚焦超声联合内分泌疗法及单纯内分泌疗法对前列腺癌的近期疗效均较好,前者疗效更为明显。
Objective To investigate the effect of transrectal high-intensity focused ultrasound combined with endocrine therapy and simple endocrine therapy on prostate cancer. Methods Forty patients with prostate cancer were divided into A and B groups. A group received HIFU combined with endocrine therapy and B group received endocrine therapy alone. HIFU treatment using Sonablate 500 transrectal HIFU treatment system, endocrine therapy using castration plus anti-androgen therapy. Follow-up time of 8 to 24 months, an average of 16 months. Results After treatment, the volume of prostate decreased and the serum PSA decreased. The IPSS score decreased and Qmax increased significantly. The difference was statistically significant before and after treatment (P <0.05). The change of group A was more obvious than that of group B, the difference was statistically significant (P <0.05). Conclusion High-intensity focused ultrasound combined with endocrine therapy and endocrine therapy alone have a good short-term effect on prostate cancer, and the former is more effective.