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目的 :探讨免疫治疗机在改善肿瘤患者化疗不良反应的疗效。方法 :2012年6月至2015年5月期间,我科诊治的90例恶性肿瘤患者,随机分为对照组(单纯采用化疗)和观察组(对照组基础上,联用免疫治疗机治疗),每组各45例,对其不良反应和KPS评分进行观察和比较。结果 :45例对照组患者化疗后有21例出现轻度疲乏,8例出现中度疲乏,4例出现重度疲乏,14例出现恶心呕吐,12例出现骨髓抑制,8例出现肝肾功能异常。45例观察组中有14例出现轻度疲乏,6例出现中度疲乏,3例出现重度疲乏,12例出现恶心呕吐,4例出现骨髓抑制,6例出现肝肾功能异常。与对照组相比,观察组的总不良反应比率明显降低(P<0.05)KPS评分改善率对照组11.8%,观察组28.9%,有显著差异(P<0.05)。结论 :免疫治疗机对化疗后不良反应及KPS评分改善有明显作用。
Objective: To investigate the effect of immunotherapy machine in improving the adverse reaction of chemotherapy in cancer patients. Methods: From June 2012 to May 2015, 90 patients with malignant tumors diagnosed and treated in our department were randomly divided into control group (chemotherapy alone) and observation group (control group, combined with immunotherapy machine) 45 cases in each group, their adverse reactions and KPS scores were observed and compared. Results: Twenty-one patients in the control group had mild fatigue after chemotherapy, moderate fatigue occurred in 8 patients, severe fatigue in 4 patients, nausea and vomiting in 14 patients, bone marrow suppression in 12 patients and abnormal liver-kidney function in 8 patients. Mild fatigue was observed in 14 of the 45 patients, moderate fatigue in 6, severe fatigue in 3, nausea and vomiting in 12, bone marrow suppression in 4 and liver and kidney dysfunction in 6. Compared with the control group, the total adverse reaction rate of the observation group was significantly lower (P <0.05). The improvement rate of KPS score was 11.8% in the control group and 28.9% in the observation group (P <0.05). Conclusion: The immunotherapy machine has a significant effect on adverse reactions after chemotherapy and improvement of KPS score.