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目的:评估无创通气(NIV)辅助治疗急性重度哮喘发作的疗效。方法:将急性重度哮喘发作患者70例随机分成对照组(n=34)和研究组(n=36),接受常规治疗和加用无创通气治疗,比较两组临床疗效。结果:两组治疗后的呼吸频率、FEV1和氧合指数较前治疗前明显改善(P<0.05),但两组间无明显差异(P>0.05);研究组中支气管舒张药吸入总量、ICU治疗时间和总住院时间均较对照组明显减少(P<0.05)。结论:NIV联合常规药物治疗可加快急性重度哮喘发作患者肺功能的改善,减少气管舒张吸入剂的需要量及缩短ICU和住院治疗时间。
PURPOSE: To evaluate the efficacy of non-invasive ventilation (NIV) in the treatment of acute severe asthma attacks. Methods: Seventy patients with acute severe asthma attack were randomly divided into control group (n = 34) and study group (n = 36). The patients received conventional therapy and non-invasive ventilation. The clinical efficacy of the two groups were compared. Results: The respiratory rate, FEV1 and oxygenation index of the two groups were significantly improved after treatment (P <0.05), but there was no significant difference between the two groups (P> 0.05). The total bronchodilator inhalation, ICU treatment time and total hospital stay were significantly reduced compared with the control group (P <0.05). Conclusion: NIV combined with conventional drug therapy can accelerate the improvement of lung function, reduce the demand of tracheal relaxant inhaler and shorten the duration of ICU and hospitalization in patients with acute severe asthma.