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已经证实在人类基因组中可能只有不到3万个蛋白编码基因,这是Venter等人发表在《SCIENCE》上的纪念碑式的工作的关键结果之一。基因数量仅增加1/3便可以从简单的线虫纲动物(Caenorhabditis elegans,约有2万个基因)进化到人类,这当然会引起争论,而且将会在新世纪的开端不容置疑地引发出科学的、哲理的、道德的和宗教的问题。同样,人类的复杂性仅仅是铜绿假单胞杆菌的5倍。虽然基因数量如此之少的结果尚有明显的不确定性,但这并非完全出乎意料,因为对两条完整的人类染色体分析,两个独立的统计学研究,以及果蝇基类数量(14000)意想不到低的结果,都已显示出基因数量减少的趋势。 自从旧的C值悖论后,现在我们手上又有了一个明显的N值悖论:不管是细胞DNA含量(质量)还是它的基因数量与我们直觉到的机体的复杂性之间都没有表现出直接
It has been demonstrated that there may be fewer than 30,000 protein-coding genes in the human genome, one of the key findings of Venter et al’s monumental work published in SCIENCE. It would of course be arguable that only a one-third increase in the number of genes can be evolved from the simple Caenorhabditis elegans (about 20,000 genes) to human beings, and this will surely spark the science at the dawn of the new millennium Philosophical, moral and religious issues. Likewise, human complexity is only five times greater than that of Pseudomonas aeruginosa. Although there are obvious uncertainties about the low number of genes, this is not entirely unexpected because of two complete human chromosome analyzes, two independent statistical studies, and the number of flies base class (14000 Unexpectedly low results have shown a tendency to reduce the number of genes. Since the old paradox of C values, we now have a clear N-value paradox in our hands: neither the cellular DNA content (mass) nor the number of its genes and the complexity of the organism we perceive Show directly