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目的探讨舒利迭干粉吸入联合小青龙汤治疗支气管哮喘的临床疗效。方法选取武汉市新洲区人民医院2014年6月—2016年6月收治的支气管哮喘患者84例,按照随机数字表法将所有患者分为对照组和观察组,各42例。对照组患者给予舒利迭干粉吸入治疗,观察组患者在对照组基础上联合小青龙汤治疗,两组患者均持续治疗8周。比较两组患者临床疗效、哮喘控制情况、呼气峰流速昼夜变异率、血氧分压、血二氧化碳分压、白介素8水平。结果观察组患者总有效率高于对照组(P<0.05)。治疗前两组患者哮喘控制测评评分表(ACT)评分与呼气峰流速昼夜变异率比较,差异无统计学意义(P>0.05);治疗后观察组患者ACT评分高于对照组,呼气峰流速昼夜变异率低于对照组(P<0.05)。治疗前两组患者血氧分压、血二氧化碳分压、白介素8水平比较,差异无统计学意义(P>0.05);治疗后观察组患者血氧分压高于对照组,血二氧化碳分压、白介素8水平低于对照组(P<0.05)。结论舒利迭干粉吸入联合小青龙汤治疗支气管哮喘的临床疗效确切,可有效缓解患者的临床症状,改善患者生活质量。
Objective To investigate the clinical efficacy of seretide combined with Xiao Qing Long Decoction in the treatment of bronchial asthma. Methods Eighty-four patients with bronchial asthma admitted from June 2014 to June 2016 in Xinzhou District People’s Hospital of Wuhan were enrolled. All patients were divided into control group and observation group according to random number table method, with 42 cases in each group. Patients in the control group were treated with inhaled Seretide dry powder. Patients in the observation group were treated with Xiao Qing Long Decoction on the basis of the control group, and both groups were treated for 8 weeks. The clinical efficacy, asthma control, diurnal variability of peak expiratory flow rate, partial pressure of blood oxygen, partial pressure of blood carbon dioxide and interleukin-8 level were compared between the two groups. Results The total effective rate in observation group was higher than that in control group (P <0.05). There was no significant difference in AST score between the two groups before and after treatment (P> 0.05). After the treatment, the ACT score of the observation group was higher than that of the control group, while the expiratory peak The rate of circadian flow rate was lower than that of the control group (P <0.05). Before treatment, there was no significant difference in partial pressure of blood pressure, partial pressure of blood carbon dioxide and level of interleukin 8 in the two groups before treatment (P> 0.05). After treatment, the partial pressure of oxygen in observation group was higher than that in control group, Interleukin-8 levels were lower in the control group (P <0.05). Conclusion The combination therapy of seretide dry powder inhalation and Xiao Qing Long Decoction in the treatment of bronchial asthma has definite curative effect, which can effectively relieve the clinical symptoms and improve the quality of life of patients.