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力生长因子(mechano growth factor,MGF)是胰岛素样生长因子1(insulin-like growth factor-1,IGF-1)的选择性剪接变异体,具有力敏感性.本文综述了MGF在组织细胞中的表达、调节及其功能机制的最新研究.首先阐述了MGF在多种细胞和组织中的表达和功能,其次说明MGF表达受应力、损伤、激素、温度等多种因素的调节.综述各项研究显示,MGF不依靠IGF-1R发挥作用,而是直接激活骨骼肌卫星细胞,促肌细胞增殖,进而促骨骼肌肥大,修复受损肌肉.通过激活Erk磷酸化促成肌细胞增殖、保护心肌细胞,上调血红素加氧酶-1(heme oxygenase-1,HO-1),激活蛋白激酶Cε(protein kinase Cε,PKCε)和NF-E2-相关因子2(NF-E2-related factor2,Nrf2)发挥保护神经的作用.另外,MGF发挥作用还可能与Wnt/β-catenin信号有关.对MGF作用及其作用机制深入研究有助于未来MGF在临床的运用.
Mechano growth factor (MGF) is a selective splicing variant of insulin-like growth factor-1 (IGF-1), which has force sensitivity. This review summarizes the effects of MGF on tissue cells Expression and regulation of MGF and its functional mechanisms.First, the expression and function of MGF in many kinds of cells and tissues were expounded, followed by the regulation of MGF expression by many factors such as stress, injury, hormone, temperature, etc.All the studies Shows that MGF does not depend on IGF-1R to play a role, but directly activates skeletal muscle satellite cells, promoting myocyte proliferation, and then promote skeletal muscle hypertrophy, repair damaged muscle.Erk phosphorylation through the activation of myocyte proliferation and protection of myocardial cells, Upregulation of heme oxygenase-1 (HO-1), activation of protein kinase Cε (PKCε) and NF-E2-related factor 2 (Nrf2) In addition, the role of MGF may also be related to Wnt / β-catenin signaling.MGF’s role and its mechanism of action in-depth study will help the future use of MGF in the clinic.