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目的探讨脱氢表雄酮(DHEA)对卵巢储备功能下降(DOR)患者在体外受精-胚胎移植(IVF-ET)周期中胚胎质量的影响。方法对接受IVF-ET助孕治疗的113例DOR的不孕症患者随机分为服用DHEA的研究组(n=65)和未服用DHEA的对照组(n=48)。服药3个月后接受IVF治疗,比较研究组患者服用DHEA前后卵巢储备功能指标,同时比较研究组和对照组患者IVF周期中胚胎质量和妊娠结局的差异。结果研究组的卵巢储备功能指标明显改善、Gn用量明显减少及胚胎质量、胚胎种植率和临床妊娠率明显提高(P<0.05);周期取消率和流产率呈降低趋势(P>0.05)。结论 DHEA可提高DOR患者的卵巢储备功能,提高胚胎质量,从而改善IVF周期妊娠结局。
Objective To investigate the effect of dehydroepiandrosterone (DHEA) on the quality of embryos in vitro fertilization-embryo transfer (IVF-ET) in patients with decreased ovarian reserve (DOR). Methods A total of 113 DOR infertile women receiving IVF-ET assisted pregnancy were randomly assigned to study group (n = 65) with DHEA and control group without DHEA (n = 48). The patients were given IVF for 3 months after treatment. The ovarian reserve function indexes before and after taking DHEA in study group were compared. The differences of embryo quality and pregnancy outcome in IVF cycle between study group and control group were also compared. Results The ovarian reserve index of the study group was significantly improved, the amount of Gn was significantly reduced and the embryo quality, embryo implantation rate and clinical pregnancy rate were significantly increased (P <0.05). The cycle cancellation rate and abortion rate showed a decreasing trend (P> 0.05). Conclusions DHEA can improve the ovarian reserve of DOR patients and improve the quality of embryo, so as to improve the IVF cycle pregnancy outcome.