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人体液中胆汁酸水平能灵敏地反映出消化系统病变,对于肝胆疾病的诊断、治疗及基础医学研究有重要价值。近年来中外学者普遍注意到肝、胆肿瘤患者血清胆汁酸水平的异常,所以人们采用多种方法对血清中的胆汁酸含量进行研究。本文采用反相高效液相色谱紫外检测器分析30例正常对照、11例肝癌患者、3例胆囊癌和7例胆道癌患者空腹血清的胆汁酸含量。分别得到血清的甘氨胆酸(GCA)、牛磺胆酸(TCA)、牛磺鹅去氧胆酸(TCDCA)、牛磺去氧胆酸(TDCA)、甘氨鹅去氧胆酸(GCDCA)、甘氨去氧胆酸
Bile acid levels in body fluids can sensitively reflect the pathological changes of the digestive system. It is of great value for the diagnosis, treatment and basic medical research of hepatobiliary diseases. In recent years, Chinese and foreign scholars have generally noticed abnormalities in serum bile acid levels in patients with liver and gallbladder tumors. Therefore, people have used various methods to study the bile acid levels in serum. In this paper, the fasting serum bile acid levels in 30 normal controls, 11 liver cancer patients, 3 gallbladder cancer patients and 7 biliary tract cancer patients were analyzed by RP-HPLC UV detector. GCA, Taurocholic Acid (TCA), Taurochenodeoxycholic Acid (TCDCA), Taurodeoxycholic Acid (TDCA), Glycochenodeoxycholic Acid (GCDCA) with serum were obtained ), Glycodeoxycholic acid