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目的:研究吸入国产噻托溴铵治疗稳定期慢性阻塞性肺疾病(COPD)的疗效和安全性。方法:将60例稳定期COPD患者分成两组,治疗组给予吸入国产噻托溴铵,对照组给予常规治疗,比较两组治疗前后肺功能、6 min步行距离、临床症状积分和急性加重次数,并观察不良反应。结果:治疗组肺功能明显好转,6 min步行距离、临床症状明显改善(P<0.05),急性加重次数减少,无严重不良反应发生。结论:国产噻托溴铵对于轻中度COPD稳定期患者疗效显著且安全可靠。
Objective: To study the efficacy and safety of inhaled domestic tiotropium in the treatment of stable chronic obstructive pulmonary disease (COPD). Methods: Sixty patients with stable COPD were divided into two groups. The treatment group was given inhaled domestic tiotropium, and the control group was given routine treatment. The pulmonary function, distance of 6 min walk, clinical symptom score and acute exacerbation were compared between two groups before and after treatment. And observed adverse reactions. Results: The lung function of the treatment group improved significantly, and the clinical symptoms were significantly improved (P <0.05) at 6 min walking distance. The number of acute exacerbations decreased and no serious adverse reactions occurred. Conclusion: The domestic Tiotropium bromide is effective and safe for patients with mild to moderate COPD in stable phase.