自从1922年发现维生素 D 与佝偻病有关以来,一直认为它不经体内代谢而直接发挥作用。1966年Deluca 等证明维生素 D 是激素的前体,其活性型1,25-(OH)_2-D_3才是与钙磷代谢有关的真正维生素D。愈来愈多的事实证明,活性维生素 D 是一种激素,对它的作用机理也有了较深入的了解。本文简要介绍维生素 D 与钙磷代谢的关系。一、活性维生素 D 的生成维生素 D 是类固醇的衍生物。 Since it was discovered in 1922 that vitamin D was associated with rickets, it has been thought that vitamin D plays a direct role without metabolism in the body. 1966 Deluca et al proved that vitamin D is a hormone precursor, its active 1,25- (OH) _2-D_3 is calcium and phosphorus metabolism-related real vitamin D. More and more facts show that active vitamin D is a hormone, its mechanism of action also has a more in-depth understanding. This article briefly describes the relationship between vitamin D and calcium and phosphorus metabolism. First, the production of active vitamin D Vitamin D is a steroid derivatives.