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最近15年来,充血性心力衰竭的治疗已经有了很大发展。目前的药物疗法一般为三类药物的联合应用:洋地贡黄甙、利尿药和扩血管药物。迄今,对利用其它药物,包括抗凝剂、抗心律失常药和β受体阻滞剂治疗心衰尚未有一致观点。相反,最近资料表明,有些药物如口服磷酸二脂酶抑制剂,某些I类抗心律失常药和钙离子通道阻滞剂实际上可能对心衰有害。 根据慢性心衰的系统理论,有几种类型的血管扩张剂可供临床医生选择。药物扩张血管可通过下列途径:直接扩张动脉,如肼苯哒嗪或通过拮抗神经
The treatment of congestive heart failure has progressed dramatically in the last 15 years. The current drug therapy is generally the combination of three types of drugs: Coumarin glycosides, diuretics and vasodilator drugs. To date, no consensus has been reached on the use of other drugs, including anticoagulants, antiarrhythmic drugs, and beta blockers in the treatment of heart failure. In contrast, recent data suggest that some drugs, such as oral phosphodiesterase inhibitors, certain type I anti-arrhythmic agents and calcium channel blockers, may actually be detrimental to heart failure. According to the systematic theory of chronic heart failure, there are several types of vasodilators available for clinicians to choose from. Drug dilation of blood vessels through the following pathways: Direct expansion of arteries, such as hydralazine or by antagonizing nerves