随着克隆化基因数量的增加,在这些克隆化基因中检出的突变数量也在不断增加。许多突变与人类疾病有重要关系,问题是能被检出的突变怎样在临床方面起重要作用。 这种重要作用对遗传病是显而易见的,但是我们不断了解到基因组中的这种改变会引起遗传性的和散发性的肿瘤发生,这就意昧着这些技术对肿瘤学具有更加重要的作用。象病毒等致病原,序列变异的鉴定不仅对流引病学的研究是重要的,而且现在有迹象表明抗药性产生机理有时与DNA水平的 As the number of cloned genes increases, the number of mutations detected in these cloned genes is also increasing. Many mutations have an important relationship with human diseases. The question is how can the detected mutations play an important role in clinical practice. This important role is obvious for genetic diseases, but we are constantly aware that this change in the genome can cause inherited and sporadic tumors, which means that these technologies have a more important role in oncology. Like pathogens such as viruses, the identification of sequence variations is not only important for the study of convalescent epidemiology, but there are now indications that the mechanism of drug resistance is sometimes associated with DNA levels.