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目的:用深慢腹式呼吸配合阻力呼吸及吸入氧气的治疗方法,对慢阻肺缓解期患者进行呼吸训练,配合卡介苗多糖核酸注射液雾化吸入,来提高患者呼吸肌的肌力和耐力,防治慢性阻塞性肺疾病(COPD)缓解期患者急性发作,从而改善肺功能、提高生活质量。方法:将120例COPD缓解期患者分为2组,每组60例。其中治疗组进行深慢腹式阻力呼吸锻炼,同时氧气吸入(5L/min),每天2次,每次15分钟进行呼吸训练,加用卡介苗多糖核酸注射液雾化吸入治疗,每次1ml,每周2次,配合常规治疗(包括止咳、祛痰、平喘等);对照组只用常规治疗,两组疗程均为3个月。测定治疗前后肺功能、动脉血气分析、运动耐力、生活质量评估及急性发作次数。结果:治疗组治疗后肺功能、PaO2、SaO2有显著改善,同时运动耐力、生活质量评估亦有提高,而且急性发作次数明显减少;对照组治疗前后肺功能、PaO2、SaO2、运动耐力、生活质量及其急性发作次数均没有明显改善。结论:应用深慢腹式呼吸配合阻力呼吸及吸入氧气进行呼吸训练,配合卡介苗多糖核酸注射液雾化吸入治疗既能改善慢阻肺缓解期患者的肺功能、PaO2、SaO2,提高其运动耐力和生活质量。又能减少慢阻肺缓解期患者急性发作次数。
OBJECTIVE: To improve the muscle strength and endurance of respiratory muscles of patients with aerosolized inhalation of BCG-polysaccharide nucleic acid injection by breathing deep and slow abdominal breathing with respiration and inhalation of oxygen, Prevention and treatment of acute exacerbation of patients with chronic obstructive pulmonary disease (COPD) remission to improve lung function and improve quality of life. Methods: 120 patients with COPD remission were divided into two groups, 60 cases in each group. The treatment group, deep and slow abdominal resistance breathing exercises, while oxygen inhalation (5L / min), 2 times a day for 15 minutes each breathing training, plus BCG polysaccharide nucleic acid injection inhalation therapy, each 1ml, each 2 times a week, with conventional treatment (including cough, expectorant, asthma, etc.); control group only conventional treatment, the two groups were treated for 3 months. Before and after treatment of lung function, arterial blood gas analysis, exercise tolerance, quality of life assessment and the number of acute attacks. Results: After treatment, the pulmonary function, PaO2 and SaO2 in the treatment group were significantly improved. At the same time, exercise endurance and quality of life were also improved, and the number of acute attacks significantly decreased. The pulmonary function, PaO2, SaO2, exercise tolerance and quality of life And the number of acute attacks did not significantly improve. Conclusion: Deep deep abdominal breathing combined with resistance breathing and inhalation of oxygen for respiratory training combined with BCG-polysaccharide nucleic acid injection can not only improve pulmonary function, PaO2 and SaO2 in patients with COPD, but also improve exercise tolerance and Quality of Life. But also reduce the number of acute exacerbation patients with COPD.