论文部分内容阅读
ＧｅＭ１０是一种抗癌生物碱－金属配位药物，动物实验发现ＧｅＭ１０对实验肿瘤Ｓ１８０肉瘤有抑制作用，能明显延长艾氏腹水癌荷瘤小鼠的存活时间，封闭荷瘤鼠体单核巨噬细胞系统，ＧｅＭ１０的抑癌作用解除。观察了ＧｅＭ１０对ＰＨＡ诱发的肿瘤患者外周血单个核细胞（ＰＢＭＣ）产生白介素－２（ＩＬ－２）能力的影响。结果发现ＧｅＭ１０能提高肿瘤患者外周血单个核细胞产生白细胞介素－２的能力（对照组：１．７９２±０．８２３；ＧｅＭ１０６０μｇ／ｍｌ２．９６５±１．１８３；Ｐ＜０．０５）。提示：ＧｅＭ１０的抗癌作用与其刺激机体免疫活性细胞、增加细胞因子的产生有关
GeM10 is an anticancer alkaloid-metal coordination drug. Animal experiments have found that GeM10 has inhibitory effects on experimental tumor S180 sarcoma and can significantly prolong the survival time of Ehrlich ascites carcinoma-bearing mice, blocking the tumor-bearing rat mononuclear giant In the phagocyte system, the inhibitory effect of GeM10 was relieved. The effect of GeM10 on the production of interleukin-2 (IL-2) in peripheral blood mononuclear cells (PBMC) from PHA-induced tumor patients was observed. The results showed that GeM10 could increase the production of interleukin-2 in peripheral blood mononuclear cells of tumor patients (control group: 1.792±0.823; GeM1060 μg/ml 2.965±1.183; P<0.05). Tip: The anti-cancer effect of GeM10 is related to its stimulation of the body’s immunocompetent cells and increased production of cytokines.