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本文综述了促性腺释放激素(GnRH)类似物的应用现状,并作了较为客观的评价。GnRH激动剂发展迅速,临床对治疗性早熟、前列腺癌、乳腺癌、子宫内膜异位、子宫肌瘤及多囊卵巢病等均有肯定效果,已成为一类重要的新药物。但作为男、女避孕药的效果却令人失望。GnRH拮抗剂则发展缓慢,但初步临床研究提示,也可能有良好的应用前景。
This review summarizes the status of the application of gonadotropin releasing hormone (GnRH) analogues and makes a more objective assessment. The rapid development of GnRH agonists, clinical treatment of precocious puberty, prostate cancer, breast cancer, endometriosis, uterine fibroids and polycystic ovary disease have a positive effect, has become an important new class of drugs. However, as male and female contraceptives, the effect has been disappointing. GnRH antagonist slow development, but preliminary clinical studies suggest that may also have a good prospect.