论文部分内容阅读
目的:分析老年原发性高血压病患者不同中医证型之间早期肾损害尿蛋白的差异性,为中医辨证分型及早期诊疗高血压肾损害提供依据。方法:采用观察研究病例资料的方法,在北京市延庆县井庄镇地区收集122例老年原发性高血压病患者,分为痰瘀阻络组、阴虚阳亢组及肾虚组3组。留取患者晨起尿液标本,检测早期肾损害指标β2-微球蛋白(β2-MG)、微量白蛋白(MALB)、转铁蛋白(TRF)。将各证型组早期肾损害指标进行统计分析。结果:所占比例痰瘀阻络组为32%,阴虚阳亢组为36%,肾虚组为32%。3个证型中阴虚阳亢组所占比例稍大,但与另外2组比较,差异无显著性意义(P>0.05)。肾虚组尿MALB、TR F、β2-MG与痰瘀阻络组、阴虚阳亢组比较,水平均增高(P<0.05,P<0.01);痰瘀阻络组与阴虚阳亢组比较,3项指标差异均无显著性意义(P>0.05)。结论:不同证型老年原发性高血压病患者均存在早期肾损害,但肾虚证患者的早期肾损害程度总体上要重于痰瘀阻络证及阴虚阳亢证患者。
OBJECTIVE: To analyze the difference of urinary protein in early renal damage among elderly patients with essential hypertension and TCM syndromes, and to provide basis for TCM syndrome differentiation and early diagnosis and treatment of hypertensive renal damage. Methods: A total of 122 elderly patients with essential hypertension were collected from Jingzhuang Town, Yanqing County, Beijing. The patients were divided into three groups: phlegm and blood stasis group, yin deficiency yangkang group and kidney deficiency group. Urine samples from patients were taken from the morning, and the indicators of early renal damage, such as β2-microglobulin (MGM), microalbumin (MALB) and transferrin (TRF) were detected. The syndromes of early renal damage indicators for statistical analysis. Results: The proportion of phlegm and blood stasis group was 32%, yin deficiency and yang hyperthyroidism group was 36%, kidney deficiency group was 32%. The three syndromes yin deficiency yang hyperthyroidism group accounted for slightly larger, but compared with the other two groups, the difference was not significant (P> 0.05). Kidney deficiency group urine MALB, TR F, β2-MG and phlegm and blood stasis group, yin deficiency and yang hyperactivity group were higher (P <0.05, P <0.01); phlegm and blood stasis group and yin deficiency and hyperactivity group There was no significant difference between the three indexes (P> 0.05). CONCLUSION: Early renal damage exists in all kinds of elderly patients with essential hypertension. However, the extent of early renal damage in patients with kidney deficiency syndrome is generally higher than that in patients with phlegm and blood stasis syndrome and yin deficiency and hyperactivity syndrome.