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目的了解金华市自然人群甲型病毒性肝炎抗体(HAV-Ig G)水平,为甲型病毒性肝炎防制提供依据。方法采用分层随机抽样方法,采集自然人群血清标本1 170份,采用酶联免疫吸附试验检测HAV-Ig G抗体。结果调查人群血清中HAV-Ig G阳性率为55.13%,不同性别、户籍和地区人群的抗体阳性率差异无统计学意义(P>0.05)。12个年龄组中抗体阳性率最高的为≥60岁组(98.89%),最低的为6岁~组(22.22%),抗体水平随年龄增长呈上升趋势(P<0.01)。检测<18月龄婴幼儿的母传HAV-Ig G水平,其中8月龄~组阳性率低至4.17%,此后的各年龄组婴幼儿均未检出阳性。在18月龄~<15岁人群中,有免疫史人群的抗体阳性率为34.81%,高于无免疫史人群的抗体阳性率19.51%(P=0.007)。结论金华市自然人群中HAV-Ig G阳性率低于全国水平,应关注甲肝疫情,并继续提高儿童免疫覆盖水平。
Objective To understand the level of hepatitis A virus (HAV-Ig G) in the natural population of Jinhua City and provide evidence for the prevention and control of hepatitis A virus. Methods The stratified random sampling method was used to collect 1 170 serum samples from the human population. The HAV-Ig G antibody was detected by enzyme-linked immunosorbent assay. Results The positive rate of HAV-Ig G in the serum of the surveyed population was 55.13%. There was no significant difference in the positive rate of antibody between different sexes, household registration and regional population (P> 0.05). The highest antibody positive rate in 12 age groups was ≥60 years old (98.89%), the lowest was 6 years old ~ (22.22%). The antibody level increased with age (P <0.01). The level of HAV-Ig G was measured in 18-month-old infants, of which the positive rate was as low as 4.17% at the age of 8 months and no positive result was detected in infants and young children of all age groups. The antibody positive rate of the population with immunization history was 34.81% between 18 months and 15 years old, which was 19.51% higher than that of the non-immunized people (P = 0.007). Conclusions The positive rate of HAV-Ig G in the natural population of Jinhua City is lower than the national level. Hepatitis A should be closely monitored and the level of immunization coverage should continue to be improved.