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BACKGROUND:Periodontitis i.e.inflammation of the periodontium is a multifactorial disease.Antimicrobial peptides (AMPs) which demonstrate a broad-spectrum of activity against varied number of bacteria,fungi,viruses,and parasites,and cancerous cells have been linked to periodontitis.The AMPs even possess the caliber of immunomodulation,and are significantly responsive to innate immuno-stimulation and infections.LL-37 plays a salubrious role by preventing and in treatment of chronic forms of periodontitis.OBJECTIVE:In the present work we will review the role of antimicrobial peptide LL-37 in periodontitis.METHODS:A systematic search was carried out from the beginning till August,2016 using the Pubmed search engine.The keywords included "LL-37," "periodontitis," "Papillon-Lefevre syndrome," "Morbus Kostmann," "Haim-Munk syndrome" along with use of Boolean operator "and."RESULTS:The search resulted in identifying 67 articles which included articles linking LL-37 with periodontitis,articles on Papillon-Lefevre syndrome,Morbus Kostmann,Haim-Munk syndrome,LL-37 and periodontitis and articles on pathogenicity of periodontitis.CONCLUSION:The literature search concluded that LL-37 plays a pivotal role in preventing and treatment of severe form of periodontitis.