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2-甲基-4-三氟甲基噻唑-5-甲酰氯是重要的农药中间体,可用于生产农药杀菌剂(如噻呋酰胺)和农药除草剂等。目前,制备2-甲基-4-三氟甲基噻唑-5-甲酰氯的工艺路线主要是选择2-甲基-4-三氟甲基噻唑-5-甲酸为原料,通过氯化得到。由于其具有毒性、腐蚀性,遇水易分解,国内2-甲基-4-三氟甲基噻唑-5-甲酰氯的生产较少。高效、优异活性的酰胺类杀菌剂噻呋酰胺的专利保护期已到期,必将进一步带动重要中间体2-甲基-4-三氟甲基噻唑-5-甲酰氯的市场需求。
2-Methyl-4-trifluoromethylthiazole-5-carboxylic acid chloride is an important pesticide intermediate, which can be used to produce pesticide fungicides (such as thifluzamide) and pesticide herbicides. At present, the preparation of 2-methyl-4-trifluoromethyl thiazole-5-carboxylic acid chloride process route is mainly selected 2-methyl-4-trifluoromethyl thiazole-5-carboxylic acid as raw material, obtained by chlorination. Due to its toxicity, corrosive, easy to break down in water, the domestic production of 2-methyl-4-trifluoromethyl thiazole-5-carboxylic acid chloride less. Efficient, excellent activity of the amide fungicide thifluzamide patent protection period has expired, will further promote the important intermediate 2-methyl-4-trifluoromethyl thiazole-5-carboxylic acid chloride market demand.