To overcome the inter-carrier interference(ICI) of orthogonal frequency division multiplexing(OFDM) systems subject to unknown carrier frequency offset(CFO) and multipath, this paper develops a blind adaptive interference suppression scheme based on independent component analysis(ICA). Taking into account statistical independence of subcarriers’ signals of OFDM, the signal recovery mechanism is investigated to achieve the goal of blind equalization. The received OFDM signals can be considered as the mixed observation signals. The effect of CFO and multipath corresponds to the mixing matrix in the problem of blind source separation(BSS) framework. In this paper, the ICAbased OFDM system model is built, and the proposed ICA-based detector is exploited to extract source signals from the observation of a received mixture based on the assumption of statistical independence between the sources. The blind separation technique can increase spectral efficiency and provide robustness performance against erroneous parameter estimation problem. Theoretical analysis and simulation results show that compared with the conventional pilot-based scheme, the improved performance of OFDM systems is obtained by the proposed ICA-based detection technique To overcome the inter-carrier interference (ICI) of orthogonal frequency division multiplexing (OFDM) systems subject to unknown carrier frequency offset (CFO) and multipath, this paper develops a blind adaptive interference suppression scheme based on independent component analysis (ICA). into account statistical independence of subcarriers’ signals of OFDM, the signal recovery mechanism is investigated to achieve the goal of blind equalization. The effect of CFO and multipath corresponds to the mixing matrix in the problem of blind source separation (BSS) framework. In this paper, the ICA-based OFDM system model is built, and the proposed ICA-based detector is exploited to extract source signals from the observation of a received mixture based on the assumption of statistical independence The blind separation technique can increase spectral efficiency and provide robustness performance Theoretical analysis and simulation results show that compared with the conventional pilot-based scheme, the improved performance of OFDM systems is obtained by the proposed ICA-based detection technique