Objective:The purpose of the study is to investigate the technical points,effects and complications of fiducial marker implantation within target areas before the CyberKnife treatment on body malignant solid tumors.Methods:Five hundred and four cases of patients with body malignant solid tumors accepted fiducial implantation within target areas under CT guidance before the treatment of CyberKnife.Observe the complications and effect.Results:Among the 504 cases,500 cases successfully accepted the implantation(a success rate of 99.2%).158 patients felt pain at the punctured sites and 3 patients had tachycardia.33 patients had abdominal pain after the surgery due to a small amount of bleeding in the needle passage during liver puncturing process.Among the 19 lung cancer patients who accepted lung paracentesis,1 case had light pneumothorax and 1 case got light haemothorax.Among the 453 patients who accepted liver paracentesis,6 had fiducial migration.Conclusion:The method of fiducial implantation within target areas before treating body malignant solid tumor with CyberKnife is minimally invasive and comparatively secure. Objective: The purpose of the study is to investigate the technical points, effects and complications of fiducial marker implantation within target areas before the CyberKnife treatment on body malignant solid tumors. Methods: Five hundred and four cases of patients with body malignant solid tumors accepted fiducial Of the 504 cases, 500 cases successfully accepted the implantation (a success rate of 99.2%). 158 patients felt pain at the punctured sites and 3 patients had tachycardia.33 patients had abdominal pain after the surgery due to a small amount of bleeding in the needle passage during liver puncturing process. Among the 19 lung cancer patients who accepted lung paracentesis, 1 case had light pneumothorax and 1 case got light haemothorax.Among the 453 patients who accepted liver paracentesis, 6 had fiducial migration.Conclusion: The method of fiducial impla ntation within target areas before treating body malignant solid tumor with CyberKnife is minimally invasive and comparatively secure.