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近年来,以足量的硫酸镁解痉治疗重度妊娠中毒症,能减少胎婴儿围产期死亡率,提高治愈率,其疗效比传统的治疗方法(解痉、降压、镇静、利尿和限盐等)有一定的提高。为此,我院试制硫酸镁葡萄糖注射液(内含2%硫酸镁和5%葡萄糖),用于我院妇产科住院患者,治疗重度妊娠中毒症,未发现有任何不良反应,临床效果比较满意,现介绍其制法及质量控制。一、配制方法 1.处方:注射用葡萄糖 500g 硫酸镁(MgSO_4·7H_2O)200g 针用活性炭 10g 注射用水加至10000ml 2.制备方法:将葡萄糖投入煮沸的注射用水中,使成约60%浓度溶液,调pH值至5.5左右,按总量的0.1%加针用活性炭,混匀,加热煮沸约15分钟,再投入硫酸镁,加注射用水至足量,搅拌,脱炭,滤至澄明,检查含量及pH值后灌装为每瓶500ml,封口,灭菌。
In recent years, adequate magnesium sulfate antispasmodic treatment of severe gestosis, can reduce perinatal mortality in infants and improve the cure rate, its efficacy than the traditional treatment methods (spasm, blood pressure, sedation, diuretic and limit Salt, etc.) have a certain increase. To this end, our hospital trial magnesium sulfate glucose injection (containing 2% magnesium sulfate and 5% glucose), used in our hospital obstetrics and gynecology inpatients, treatment of severe gestosis, did not find any adverse reactions, the clinical effect comparison Satisfaction, now introduced its system of law and quality control. First, the preparation method 1. Prescription: 500g of glucose for injection Magnesium sulfate (MgSO4-7H2O) 200g needle activated carbon 10g water for injection added to 10000ml 2. Preparation: Put glucose into boiling water for injection, so that about 60% concentration solution , Adjust the pH to 5.5 or so, according to the total amount of 0.1% plus acupuncture with activated carbon, mix, heat boil for about 15 minutes, then put magnesium sulfate, add water for injection to the full, stirring, decarbonization, Content and pH value of the bottle after filling 500ml, sealed, sterilized.