【摘 要】
：
Long noncoding RNAs(IncRNAs)act as essential regulators of various diseases.However,the func-tions of IncRNAs in sepsis-induced acute lung injury(SALI)remain unclear.Here,we found that lipopolysaccharide could upregulate IncRNA-p21 expression in mesenchym
【机 构】
：
Emergency Department,The First Hospital of China Medical University,Shenyang 110001,China
论文部分内容阅读
Long noncoding RNAs(IncRNAs)act as essential regulators of various diseases.However,the func-tions of IncRNAs in sepsis-induced acute lung injury(SALI)remain unclear.Here,we found that lipopolysaccharide could upregulate IncRNA-p21 expression in mesenchymal stem cells(MSCs)in a time-and dose-dependent manner and that IncRNA-p21 was packaged into exosomes.Further-more,we demonstrated that treatment with exosomal IncRNA-p21 could increase the expression of sirtuin 1(SIRT1)to protect MLE-12 cells from apoptosis during sepsis.Moreover,we identified SIRT1 as a direct target of miR-181 and found that the level of SIRT1 was negatively correlated with the level of miR-181.The luciferase reporter assay also confirmed the negative correlation between the levels of miR-181 and IncRNA-p21.Our results showed that the IncRNA-p21-induced downregulation of miR-181 might suppress epithelial cell apoptosis and alleviate lung tissue injury by upregulating SIRT1 expression,suggesting the potential therapeutic effects of IncRNA-p21 on SALI.In conclusion,we found that the novel lncRNA-p21/miR-181/SIRT1 pathway may play an important role in the progression of SALI,and MSC-derived exosomes may be a new therapeutic strategy for this disease.
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