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目的观察综合治疗(药物、心理、康复)帕金森病患者伴神经精神症状的临床疗效,探讨如何改善其生活质量。方法将58例帕金森病伴有神经精神症状患者随机分为治疗组30例,对照组28例。两组均常规服用抗帕金森病药物治疗运动症状。针对帕金森患者神经精神症状治疗组患者给予综合治疗,包括药物(中、西药)、心理辅导、康复治疗。结果治疗前HAMD评分比较两组差异无统计学意义(P>0.05)。治疗后两组HAMD量表评分得分较治疗前明显下降(P<0.05);治疗组治疗后HAMD评分与对照组有明显下降(P<0.05),差异具有统计学意义。结论需重视帕金森患者的非运动症状对其生活质量的影响,同运动症状相似,非运动症状的治疗需以药物为主,尤其需积极对其神经精神症状进行药物、心理、康复等综合治疗。
Objective To observe the clinical curative effect of neuropsychiatric symptoms in patients with Parkinson’s disease in comprehensive treatment (drug, psychology and rehabilitation) and to explore how to improve their quality of life. Methods Fifty-eight patients with neuropsychiatric symptoms of Parkinson’s disease were randomly divided into treatment group (n = 30) and control group (n = 28). Both groups routinely took anti-Parkinson’s disease medications to treat motor symptoms. For Parkinson’s patients neuropsychiatric symptoms treatment group patients given comprehensive treatment, including drugs (Chinese and Western medicine), psychological counseling, rehabilitation. Results HAMD score before treatment was no significant difference between the two groups (P> 0.05). After treatment, the score of HAMD in both groups decreased significantly (P <0.05). The HAMD score of the treatment group decreased significantly compared with that of the control group (P <0.05), and the difference was statistically significant. Conclusions It is necessary to pay attention to the effect of non-motor symptoms of Parkinson’s patients on their quality of life. Similar to motor symptoms, the treatment of non-motor symptoms should be based on drugs. In particular, comprehensive treatment of neuropsychiatric symptoms such as drug, psychology and rehabilitation should be actively carried out .