论文部分内容阅读
目的：研究妇科肿瘤患者血清中细胞因子的变化，探索与发病机理的相关性。方法：以双抗体夹心ＥＬＩＳＡ法对７９例妇科肿瘤患者血清中肿瘤坏死因子（ＴＮＦ－α）、白细胞介素－６（ＩＬ－６）、白细胞介素－８（ＩＬ－８）和白细胞介素－１０（ＩＬ－１０）水平进行了监测。结果：妇科恶性肿瘤组ＴＮＦ－α、ＩＬ－６、ＩＬ－８和ＩＬ－１０水平均明显高于正常对照组和妇科良性肿瘤组（Ｐ＜０．０１），其中尤以卵巢癌增高最为明显，其次为子宫内膜癌和滋养细胞肿瘤。结论：说明ＴＮＦ－α、ＩＬ－６、ＩＬ－８和ＩＬ－１０细胞因子可能参与肿瘤的形成和发展过程，并对妇科良、恶性肿瘤的鉴别诊断有一定意义。
Objective: To study the changes of serum cytokines in gynecologic oncology patients and to explore the correlation with the pathogenesis. Methods: Tumor necrosis factor (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin -10 (IL-10) levels were monitored. Results: The levels of TNF-α, IL-6, IL-8 and IL-10 in gynecological malignant tumor group were significantly higher than those in normal control group and benign gynecologic tumor group (P <0.01), especially in ovarian cancer , Followed by endometrial cancer and trophoblastic tumors. Conclusion: It is concluded that TNF-α, IL-6, IL-8 and IL-10 cytokines may be involved in the formation and development of tumors, and have certain significance for the differential diagnosis of benign and malignant tumors of gynecology.